Clean URLs are great for getting up in the search results, and they give more meaningful links for users too.
Here’s how to set them up in WordPress 3.5.
1. Settings->Permalinks
2. Choose ‘post name’.
3. Update .htaccess using the code at the bottom of the page. WordPress can do that automatically if it has permission to write to .htaccess.
More documentation here if you want to use custom clean URLs.